Here's a piece of advice for you:
Know where you want your book to be published before you ever sit down to create, and then have a backup plan for that in case the book is rejected. (This is if you're looking for a publisher. If you aren't, then this advice isn't for you.)
Why do you want to do this? Because you could create a book that is solid in all ways except commercially.
I know it sounds like I'm saying something in a foreign language, but businesses exist to make money. If they want to stay in business, doing what they do, then money has to come from somewhere. Even for non-profit organizations. (Know what non-profit means in a business sense? That the first goal of the business isn't to make money. Money may be a secondary thing, but it isn't primary. That's all. People still need to be paid for the things they do.)
From a publishing standpoint, this means a publisher wants a book they can sell. This means that the book has to be salable. Comic publishers aren't charities. They have to at least break even. If they can't do that on your book that is solid in every way but not salable, then you have a problem with the book.
As the Editor in Chief of ComixTribe, I recently had to weigh in on a beautiful book. The book was good in every way...except that we couldn't sell it. The art wasn't right for our audience. While I'm sure that we weren't first on this creator's list, I'm faintly curious as to who else passed on the book for it to get to us. This work wouldn't have been on our radar at all. While we've published C is for Cthulhu and And Then Emily Was Gone, one is a cute children's book and the other is a horror tale. Both had what could be seen as quirky art, but within the genre of the books, they worked. You can have a lot of leeway with horror.
Do yourself a favor: know where you want the book to be published first, and know what kind of books that publisher puts out. If your book doesn't fit, you could end up with a beautiful book that no one will see.